Burt Gummer (Michael Gross) and his son Travis Welker (Jamie Kennedy) are called to a research facility in the frozen tundra of the Canadian Arctic. They find themselves up to their ears in Graboids and Ass-Blasters investigating a series of deadly giant-worm attacks. Burt begins to suspect that Graboids are secretly being weaponized, but before he can prove his theory, he is sidelined by Graboid venom. With just 48 hours to live, the only hope is to create an antidote from fresh venom — but to do that, someone will have to figure out how to milk a Graboid!