Confined to an asylum for the criminally insane for the past four years, Nica Pierce (Fiona Dourif) is wrongly convinced that she, not Chucky, murdered her entire family. But when her psychiatrist introduces a new therapeutic "tool" to facilitate his patients' group sessions - an all-too-familiar "Good Guy" doll with an innocently smiling face - a string of grisly deaths begins to plague the asylum. Andy Barclay (Alex Vincent), Chucky's now-grown-up nemesis from the original Child's Play, races to Nica's aid. But to save her he'll have to get past Tiffany (Oscar®-nominee Jennifer Tilly), Chucky's long-ago bride, who will do anything, no matter how deadly or depraved, to help her beloved devil doll.